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Lymph node fibroblastic reticular cells in health and disease

Fletcher, AL; Acton, SE; Knoblich, K; (2015) Lymph node fibroblastic reticular cells in health and disease. [Review]. Nature Reviews Immunology , 15 (6) pp. 350-361. 10.1038/nri3846. Green open access

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Abstract

Over the past decade, a series of discoveries relating to fibroblastic reticular cells (FRCs) — immunologically specialized myofibroblasts found in lymphoid tissue — has promoted these cells from benign bystanders to major players in the immune response. In this Review, we focus on recent advances regarding the immunobiology of lymph node-derived FRCs, presenting an updated view of crucial checkpoints during their development and their dynamic control of lymph node expansion and contraction during infection. We highlight the robust effects of FRCs on systemic T and B cell responses and present an emerging view of FRCs as drivers of pathology following acute and chronic viral infections. Lastly, we review emerging therapeutic advances harnessing the immunoregulatory properties of FRCs

Type: Article
Title: Lymph node fibroblastic reticular cells in health and disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nri3846
Publisher version: http://doi.org/10.1038/nri3846
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Humoral immunity, Innate lymphoid cells, Lymph node, Lymphocyte activation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1548192
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