Donadoni, F;
Pichardo, C;
Bartlett, M;
Dardik, A;
Homer-Vanniasinkam, S;
Diaz, V;
(2017)
Patient-Specific, Multi-Scale Modeling of Neointimal Hyperplasia in Vein Grafts.
Frontiers in Physiology
, 8
, Article 226. 10.3389/fphys.2017.00226.
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Abstract
Neointimal hyperplasia is amongst the major causes of failure of bypass grafts. The disease progression varies from patient to patient due to a range of different factors. In this paper, a mathematical model will be used to understand neointimal hyperplasia in individual patients, combining information from biological experiments and patient-specific data to analyze some aspects of the disease, particularly with regard to mechanical stimuli due to shear stresses on the vessel wall. By combining a biochemical model of cell growth and a patient-specific computational fluid dynamics analysis of blood flow in the lumen, remodeling of the blood vessel is studied by means of a novel computational framework. The framework was used to analyze two vein graft bypasses from one patient: a femoro-popliteal and a femoro-distal bypass. The remodeling of the vessel wall and analysis of the flow for each case was then compared to clinical data and discussed as a potential tool for a better understanding of the disease. Simulation results from this first computational approach showed an overall agreement on the locations of hyperplasia in these patients and demonstrated the potential of using new integrative modeling tools to understand disease progression.
| Type: | Article |
|---|---|
| Title: | Patient-Specific, Multi-Scale Modeling of Neointimal Hyperplasia in Vein Grafts |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fphys.2017.00226 |
| Publisher version: | https://doi.org/10.3389/fphys.2017.00226 |
| Language: | English |
| Additional information: | © 2017 Donadoni, Pichardo-Almarza, Bartlett, Dardik, Homer-Vanniasinkam and Díaz-Zuccarini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Neointimal hyperplasia, vein grafts, remodeling, shear stress, computational fluid dynamics, multi-scale modeling |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1547449 |
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