Tremblay, S;
Hannah, R;
Rawji, V;
Rothwell, JC;
(2017)
Modulation of iTBS after-effects via concurrent directional TDCS: a proof of principle study.
Brain Stimulation
, 10
(4)
pp. 744-747.
10.1016/j.brs.2017.03.009.
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Abstract
BACKGROUND: Experiments in animals have shown that electrical polarisation of neurons in the hippocampus can modulate the long-term effects of theta burst stimulation on synaptic strength. OBJECTIVE: We examined whether a similar phenomenon could also be observed in human motor cortex (M1) using transcranial direct current stimulation (TDCS) to polarise neurons during unidirectional intermittent theta burst stimulation (iTBS). METHODS: TDCS was applied during posterior-anterior iTBS using three different conditions: posterior-anterior TDCS (anode 3.5 cm posterior to M1, cathode 3.5 cm anterior to M1), anterior-posterior TDCS (cathode 3.5 cm posterior to M1, anode 3.5 cm anterior to M1), and sham TDCS. RESULT: We found that when the direction of TDCS (posterior-anterior) matched the direction of the electrical field induced by iTBS, excitability changes were increased by 12% in comparison with iTBS combined with sham TDCS. When the TDCS was reversed (anterior-posterior), the excitatory effect of iTBS was abolished. CONCLUSION: Our findings suggest that excitatory after-effects of iTBS can be modulated by directionally-specific TDCS.
| Type: | Article |
|---|---|
| Title: | Modulation of iTBS after-effects via concurrent directional TDCS: a proof of principle study |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.brs.2017.03.009 |
| Publisher version: | http://dx.doi.org/10.1016/j.brs.2017.03.009 |
| Language: | English |
| Additional information: | © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Transcranial magnetic stimulation; Intermittent theta burst stimulation; Transcranial direct current stimulation; Primary motor cortex |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1546284 |
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