Gardiner, C;
Vatish, M;
(2017)
Impact of haemostatic mechanisms on pathophysiology of preeclampsia.
Thrombosis Research
, 151
(Suppl 1)
S48-S52.
10.1016/S0049-3848(17)30067-1.
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Abstract
Preeclampsia (PE) is disorder of new onset hypertension and proteinuria during the second half of pregnancy. There is increasing evidence to implicate placental over-expression of tissue factor and PAR-1 in the pathophysiology of PE. Excessive activation of platelets, neutrophils and the complement system may also contribute to the placental pathology and maternal endothelial responsible for the symptoms of PE. Increased knowledge in this field may identify new therapeutic strategies for the treatment of PE.
| Type: | Article |
|---|---|
| Title: | Impact of haemostatic mechanisms on pathophysiology of preeclampsia |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/S0049-3848(17)30067-1 |
| Publisher version: | http://dx.doi.org/10.1016/S0049-3848(17)30067-1 |
| Language: | English |
| Additional information: | This manuscript version is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at https://creativecommons.org/licenses/. Access may be initially restricted by the publisher. |
| Keywords: | Haemostasis, Platelets, Preeclampsia, Syncytiotrophoblast, Tissue factor |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1546233 |
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