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Deciphering Genetic Intratumor Heterogeneity and Its Impact on Cancer Evolution

Rosenthal, R; McGranahan, N; Herrero, J; Swanton, C; (2017) Deciphering Genetic Intratumor Heterogeneity and Its Impact on Cancer Evolution. Annual Review of Cancer Biology , 1 pp. 223-240. 10.1146/annurev-cancerbio-042516-011348. Green open access

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Abstract

Cancer is a disease reliant on the generation of mutations and the subsequent selection of those subpopulations endowed with the greatest fitness advantage. Beginning with a heterogeneous landscape of somatic alterations, various selective pressures acting on a tumor can shape the way it evolves. In this review, we first discuss the current bioinformatics tools available to tease apart the heterogeneous nature of a tumor and second consider the impact that evolutionary forces have on sculpting a tumor. Neighboring subclones may alter the microenvironment cultivating either cooperation or competition between clonal populations. Additionally, the harsh environment brought about by therapy and the immune system may force adaptation. Finally, we examine recent analyses focused on precancerous samples, which help to reveal clonal selection occurring during the earliest stages of tumor development, as well as work that has identified patterns of somatic evolution observed in normal tissues.

Type: Article
Title: Deciphering Genetic Intratumor Heterogeneity and Its Impact on Cancer Evolution
Open access status: An open access version is available from UCL Discovery
DOI: 10.1146/annurev-cancerbio-042516-011348
Publisher version: http://dx.doi.org/10.1146/annurev-cancerbio-042516...
Language: English
Additional information: Copyright © 2017, Annual Reviews. This is a preprint of a forthcoming article accepted for publication in the Annual Review of Cancer Biology.
Keywords: Intratumor heterogeneity, bioinformatics tools, clonal selection, Darwinian evolution, chemotherapy
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/1545871
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