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Invasive or non-invasive imaging for detecting high-risk coronary lesions?

Patel, K; Tarkin, J; Serruys, PW; Tenekecioglu, E; Foin, N; Zhang, YJ; Crake, T; ... Bourantas, CV; + view all (2017) Invasive or non-invasive imaging for detecting high-risk coronary lesions? Expert Review of Cardiovascular Therapy , 15 (3) pp. 165-179. 10.1080/14779072.2017.1297231. Green open access

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Abstract

INTRODUCTION: Advances in our understanding about atherosclerotic evolution have enabled us to identify specific plaque characteristics that are associated with coronary plaque vulnerability and cardiovascular events. With constant improvements in signal and image processing an arsenal of invasive and non-invasive imaging modalities have been developed that are capable of identifying these features allowing in vivo assessment of plaque vulnerability. Areas covered: This review article presents the available and emerging imaging modalities introduced to assess plaque morphology and biology, describes the evidence from the first large scale studies that evaluated the efficacy of invasive and non-invasive imaging in detecting lesions that are likely to progress and cause cardiovascular events and discusses the potential implications of the in vivo assessment of coronary artery pathology in the clinical setting. Expert commentary: Invasive imaging, with its high resolution, and in particular hybrid intravascular imaging appears as the ideal approach to study the mechanisms regulating atherosclerotic disease progression; whereas non-invasive imaging is expected to enable complete assessment of coronary tree pathology, detection of high-risk lesions, more accurate risk stratification and thus to allow a personalized treatment of vulnerable patients.

Type: Article
Title: Invasive or non-invasive imaging for detecting high-risk coronary lesions?
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/14779072.2017.1297231
Publisher version: http://doi.org/10.1080/14779072.2017.1297231
Language: English
Additional information: © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way
Keywords: Atherosclerosis, computed tomographic coronary angiography, intravascular ultrasound, optical coherence tomography, positron emission tomography, vulnerable plaque
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science
URI: https://discovery.ucl.ac.uk/id/eprint/1544195
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