Blombach, F;
Grohmann, D;
(2017)
Same same but different: the evolution of TBP in archaea and their eukaryotic offspring.
Transcription
, 8
(3)
pp. 162-168.
10.1080/21541264.2017.1289879.
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Abstract
Transcription factors TBP and TF(II)B assemble with RNA polymerase and the promoter DNA forming the initiation complex. Despite a high degree of conservation, the molecular binding mechanisms of archaeal and eukaryotic TBP and TF(II)B differ significantly. Based on recent biophysical data, we speculate how the mechanisms co-evolved with transcription regulation and TBP multiplicity.
| Type: | Article |
|---|---|
| Title: | Same same but different: the evolution of TBP in archaea and their eukaryotic offspring |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/21541264.2017.1289879 |
| Publisher version: | http://dx.doi.org/10.1080/21541264.2017.1289879 |
| Language: | English |
| Additional information: | This is an Accepted Manuscript of an article published by Taylor & Francis in Transcription on 08 Feb 2014, available online: http://www.tandfonline.com/10.1080/21541264.2017.1289879. |
| Keywords: | TBP, TFB, transcription initiation, single-molecule FRET, transcription factors, archaea |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1544169 |
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