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Same same but different: the evolution of TBP in archaea and their eukaryotic offspring

Blombach, F; Grohmann, D; (2017) Same same but different: the evolution of TBP in archaea and their eukaryotic offspring. Transcription , 8 (3) pp. 162-168. 10.1080/21541264.2017.1289879. Green open access

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Abstract

Transcription factors TBP and TF(II)B assemble with RNA polymerase and the promoter DNA forming the initiation complex. Despite a high degree of conservation, the molecular binding mechanisms of archaeal and eukaryotic TBP and TF(II)B differ significantly. Based on recent biophysical data, we speculate how the mechanisms co-evolved with transcription regulation and TBP multiplicity.

Type: Article
Title: Same same but different: the evolution of TBP in archaea and their eukaryotic offspring
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/21541264.2017.1289879
Publisher version: http://dx.doi.org/10.1080/21541264.2017.1289879
Language: English
Additional information: This is an Accepted Manuscript of an article published by Taylor & Francis in Transcription on 08 Feb 2014, available online: http://www.tandfonline.com/10.1080/21541264.2017.1289879.
Keywords: TBP, TFB, transcription initiation, single-molecule FRET, transcription factors, archaea
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1544169
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