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Strong Evidence for Pattern Separation in Human Dentate Gyrus

Berron, D; Schuetze, H; Maass, A; Cardenas-Blanco, A; Kuijf, HJ; Kumaran, D; Duezel, E; (2016) Strong Evidence for Pattern Separation in Human Dentate Gyrus. Journal of Neuroscience , 36 (29) pp. 7569-7579. 10.1523/JNEUROSCI.0518-16.2016. Green open access

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Abstract

The hippocampus is proposed to be critical in distinguishing between similar experiences by performing pattern separation computations that create orthogonalized representations for related episodes. Previous neuroimaging studies have provided indirect evidence that the dentate gyrus (DG) and CA3 hippocampal subregions support pattern separation by inferring the nature of underlying representations from the observation of novelty signals. Here, we use ultra-high-resolution fMRI at 7 T and multivariate pattern analysis to provide compelling evidence that the DG subregion specifically sustains representations of similar scenes that are less overlapping than in other hippocampal (e.g., CA3) and medial temporal lobe regions (e.g., entorhinal cortex). Further, we provide evidence that novelty signals within the DG are stimulus specific rather than generic in nature. Our study, in providing a mechanistic link between novelty signals and the underlying representations, constitutes the first demonstration that the human DG performs pattern separation.

Type: Article
Title: Strong Evidence for Pattern Separation in Human Dentate Gyrus
Open access status: An open access version is available from UCL Discovery
DOI: 10.1523/JNEUROSCI.0518-16.2016
Publisher version: http://dx.doi.org/10.1523/JNEUROSCI.0518-16.2016
Language: English
Additional information: Copyright © 2016 the authors. Creative Commons Attribution Noncommercial-Share Alike 3.0 Unported License (http://creativecommons.org/licenses/by-nc-sa/3.0).
Keywords: 7 T fMRI, hippocampal subfields, medial temporal lobe, memory, MVPA, pattern separation, High-resolution Fmri, Complementary-learning-systems, Human Hippocampal Subfields, Neural Representations, Entorhinal Cortex, Memory, CA3, Registration, Activation, Completion
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/1543980
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