Li, X;
Koller, G;
Huang, J;
Di Silvio, L;
Renton, T;
Esat, M;
Bonfield, W;
(2010)
A novel jet-based nano-hydroxyapatite patterning technique for osteoblast guidance.
Journal of the Royal Society Interface
, 7
(42)
189 - 197.
10.1098/rsif.2009.0101.
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Abstract
Surface topography is well known to play a crucial role in influencing cellular responses to an implant material and is therefore important in bone tissue regeneration. A novel jet-based patterning technique, template-assisted electrohydrodynamic atomization spraying, was recently devised to control precisely the surface structure as well as its dimensions. In the present study, a detailed investigation of this patterning process was carried out. A range of nano-hydroxyapatite (nHA) line-shaped patterns <20 mu m in width were successfully deposited on a commercially pure Ti surface by controlling the flow of an nHA suspension in an electric field. In vitro studies showed that the nHA patterns generated are capable of regulating the human osteoblast cell attachment and orientation.
| Type: | Article |
|---|---|
| Title: | A novel jet-based nano-hydroxyapatite patterning technique for osteoblast guidance |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1098/rsif.2009.0101 |
| Publisher version: | http://doi.org/10.1098/rsif.2009.0101 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | surface topography, hydroxyapatite, nanoparticles, template-assisted, electrohydrodynamic, spraying |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/154333 |
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