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Epithelial cell migration as a potential therapeutic target in early lung cancer.

Millar, FR; Janes, SM; Giangreco, A; (2017) Epithelial cell migration as a potential therapeutic target in early lung cancer. Eur Respir Rev , 26 (143) , Article 160069. 10.1183/16000617.0069-2016. Green open access

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Abstract

Lung cancer is the most lethal cancer type worldwide, with the majority of patients presenting with advanced stage disease. Targeting early stage disease pathogenesis would allow dramatic improvements in lung cancer patient survival. Recently, cell migration has been shown to be an integral process in early lung cancer ontogeny, with preinvasive lung cancer cells shown to migrate across normal epithelium prior to developing into invasive disease. TP53 mutations are the most abundant mutations in human nonsmall cell lung cancers and have been shown to increase cell migration via regulation of Rho-GTPase protein activity. In this review, we explore the possibility of targeting TP53-mediated Rho-GTPase activity in early lung cancer and the opportunities for translating this preclinical research into effective therapies for early stage lung cancer patients.

Type: Article
Title: Epithelial cell migration as a potential therapeutic target in early lung cancer.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1183/16000617.0069-2016
Publisher version: http://dx.doi.org/10.1183/16000617.0069-2016
Language: English
Additional information: ERR articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1543034
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