Tansley, SL;
Betteridge, ZE;
Simou, S;
Jacques, TS;
Pilkington, C;
Wood, M;
Warrier, K;
... Juvenile Dermatomyositis Research Group; + view all
(2017)
Anti-HMGCR Autoantibodies in Juvenile Idiopathic Inflammatory Myopathies Identify a Rare but Clinically Important Subset of Patients.
The Journal of Rheumatology
, 44
(4)
pp. 488-492.
10.3899/jrheum.160871.
Preview |
Text
Jacques_Anti-HMGCR Autoantibodies in Juvenile Idiopathic.pdf - Accepted Version Download (891kB) | Preview |
Abstract
OBJECTIVE: We aimed to establish the prevalence and clinical associations of anti-HMG-CoA-reductase (anti-HMGCR) in a large UK cohort with juvenile myositis. METHODS: There were 381 patients investigated for anti-HMGCR using ELISA. RESULTS: Anti-HMGCR autoantibodies were detected in 4 patients (1%). These children had no or minimal rash and significant muscle disease. Muscle biopsies were considered distinctive, with widespread variation in fiber size, necrotic fibers, and chronic inflammatory cell infiltrates; all had prolonged elevation of creatine kinase and all ultimately received biologic therapies. CONCLUSION: Anti-HMGCR in UK children with myositis are associated with severe disease that is poorly responsive to standard treatment.
Archive Staff Only
 |
View Item |
