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On the relative performance of edge illumination x-ray phase contrast CT and conventional, attenuation-based CT

Hagen, CK; Diemoz, PC; Olivo, A; (2017) On the relative performance of edge illumination x-ray phase contrast CT and conventional, attenuation-based CT. Medical Physics , 44 (5) pp. 1876-1885. 10.1002/mp.12179. Green open access

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Abstract

Purpose This article is aimed at comparing edge illumination (EI) x-ray phase contrast computed tomography (PCT) and conventional (attenuation-based) computed tomography (CT), based on their respective contrast and noise transfer. Methods The noise in raw projections obtained with EI PCT is propagated through every step of the data processing, including phase retrieval and tomographic reconstruction, leading to a description of the noise in the reconstructed phase tomograms. This is compared to the noise in corresponding attenuation tomograms obtained with CT. Specifically, a formula is derived that allows evaluating the relative performance of both modalities on the basis of their contrast-to-noise ratio (CNR), for a variety of experimental parameters. Results The noise power spectra of phase tomograms are shifted towards lower spatial frequencies, leading to a fundamentally different noise texture. The relative performance of EI PCT and CT, in terms of their CNR, is linked to spatial resolution: the CNR in phase tomograms is generally superior to that in attenuation tomograms for higher spatial resolutions (tens to hundreds of μm), but inferior for lower spatial resolutions (hundreds of μm to mm). Conclusions These results imply that EI PCT could outperform CT in applications for which high spatial resolutions are key, i.e. small animal or specimen imaging. This article is protected by copyright. All rights reserved.

Type: Article
Title: On the relative performance of edge illumination x-ray phase contrast CT and conventional, attenuation-based CT
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/mp.12179
Publisher version: http://dx.doi.org/10.1002/mp.12179
Language: English
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1542415
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