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Risk factors for ocular surface squamous neoplasia in Kenya: a case-control study

Gichuhi, S; Macharia, E; Kabiru, J; Zindamoyen, AM; Rono, H; Ollando, E; Wachira, J; ... Burton, MJ; + view all (2016) Risk factors for ocular surface squamous neoplasia in Kenya: a case-control study. Tropical Medicine & International Health , 21 (12) pp. 1522-1530. 10.1111/tmi.12792. Green open access

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Abstract

Objective To determine modifiable risk factors of ocular surface squamous neoplasia (OSSN) in Kenya using disease-free controls. Methods Adults with conjunctival lesions were recruited at four eye care centres in Kenya and underwent excision biopsy. An equal number of controls having surgery for conditions not affecting the conjunctiva and unrelated to ultraviolet light were group-matched to cases by age group, sex and eye care centre. Associations of risk factors with OSSN were evaluated using multivariable logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). Continuous variables were compared using the t-test or the Wilcoxon–Mann–Whitney U-test depending on their distribution. Results A total of 131 cases and 131 controls were recruited. About two-thirds of participants were female, and the mean age of cases and controls was 42.1 years and 43.3 years, respectively. Risk factors for OSSN were HIV infection without antiretroviral therapy (ART) use (OR = 48.42; 95% CI: 7.73–303.31) and with ART use (OR = 19.16; 95% CI: 6.60–55.57), longer duration of exposure to the sun in the main occupation (6.9 h/day vs. 4.6 h/day, OR = 1.24; 95% CI: 1.10–1.40) and a history of allergic conjunctivitis (OR = 74.61; 95% CI: 8.08–688.91). Wearing hats was protective (OR = 0.22; 95% CI: 0.07–0.63). Conclusion Measures to prevent and control HIV, reduce sun exposure such as wearing hats and control allergic conjunctivitis are recommended.

Type: Article
Title: Risk factors for ocular surface squamous neoplasia in Kenya: a case-control study
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/tmi.12792
Publisher version: http://doi.org/10.1111/tmi.12792
Language: English
Additional information: Copyright © 2017 The Authors. Tropical Medicine & International Health Published by John Wiley & Sons Ltd. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Science & Technology, Life Sciences & Biomedicine, Public, Environmental & Occupational Health, Tropical Medicine, ocular surface squamous neoplasia, risk factors, ultraviolet radiation, HIV, antiretroviral therapy, allergic conjunctivitis, Human-papillomavirus Infection, Vitamin-A-deficiency, Cell Carcinoma, Vernal Keratoconjunctivitis, Conjunctival Carcinoma, Ultraviolet-radiation, Clinical-presentation, Confocal Microscopy, Corneal, Africa
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1542333
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