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Neuromyelitis optica spectrum disorder related tonic spasms responsive to lacosamide

Baheerathan, A; Brownlee, WJ; Rugg-Gunn, F; Chard, DT; Trip, SA; (2017) Neuromyelitis optica spectrum disorder related tonic spasms responsive to lacosamide. Multiple Sclerosis and Related Disorders , 13 pp. 73-74. 10.1016/j.msard.2017.02.009. Green open access

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Abstract

Paroxysmal tonic spasms [PTS] are common in patients with neuromyelitis optica spectrum disorder (NMOSD).1 2 In patients with demyelinating disease, PTS can significantly reduce the quality of life, limit activities of daily living and the rehabilitative process following an acute relapse 3. As in patients with multiple sclerosis (MS), paroxysmal tonic spasms in NMOSD usually respond well to treatment with carbamazepine.2 However, the optimal treatment in patients where carbamazepine is contraindicated or poorly tolerated is unclear. We describe a patient with NMOSD with severe paroxysmal tonic spasms who did not tolerate carbamazepine but was successfully treated with lacosamide (Vimpat).

Type: Article
Title: Neuromyelitis optica spectrum disorder related tonic spasms responsive to lacosamide
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.msard.2017.02.009
Publisher version: http://dx.doi.org/10.1016/j.msard.2017.02.009
Language: English
Additional information: © 2017 Elsevier B.V. All rights reserved. This manuscript version is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at https://creativecommons.org/licenses/. Access may be initially restricted by the publisher.
Keywords: NMOSD; Paroxysomal tonic spasms; Pharmacotherapy
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/1542326
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