UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Validation of an MRI Rating Scale for Amyloid-Related Imaging Abnormalities

Bechten, A; Wattjes, MP; Purcell, DD; Aliaga, ES; Daams, M; Brashear, HR; Arrighi, HM; (2017) Validation of an MRI Rating Scale for Amyloid-Related Imaging Abnormalities. Journal of Neuroimaging , 27 (3) pp. 318-325. 10.1111/jon.12422. Green open access

[thumbnail of Bechten - ARIA rating scale - JON-16-4805.R1.pdf]
Preview
Text
Bechten - ARIA rating scale - JON-16-4805.R1.pdf - Accepted Version

Download (1MB) | Preview

Abstract

INTRODUCTION: Immunotherapeutic agents against amyloid beta (Aβ) are associated with adverse events, including amyloid-related imaging abnormalities with edema and effusion (ARIA-E). Recently, a magnetic resonance imaging (MRI) rating scale was developed for ARIA-E detection and classification. The aim of this study was to validate the use of this rating scale in a larger patient group with multiple raters. METHODS: MRI scans of 75 patients (29 with known ARIA-E and 46 control subjects) were analyzed by five neuroradiologists with different degrees of expertise, according to the ARIA-E rating scale. For each patient, we included a baseline and a follow-up fluid-attenuated inversion recovery image. Interrater agreement was calculated using intraclass correlation coefficient (ICC). RESULTS: On average, 4.1% of the ARIA-E cases were missed. We observed a high interrater agreement for scores of sulcal hyperintensity (SH; ICC = .915; 95% CI 85-95) and for the combined scores of the 2 ARIA-E findings, parenchymal hyperintensity (PH) and SH (ICC = .878; 95% CI 79-93). A slightly lower agreement for PH (ICC = .678; 95% CI 51-81) was noted. CONCLUSION: The ARIA-E rating scale is a simple tool to evaluate the extent of ARIA-E in patients recruited into Aβ-lowering therapeutic trials. It shows high interrater agreement among raters with different degrees of expertise.

Type: Article
Title: Validation of an MRI Rating Scale for Amyloid-Related Imaging Abnormalities
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/jon.12422
Publisher version: http://dx.doi.org/10.1111/jon.12422
Language: English
Additional information: This is the peer reviewed version of the following article: Bechten, A., Wattjes, M. P., Purcell, D. D., Aliaga, E. S., Daams, M., Brashear, H. R., Arrighi, H. M. and Barkhof, F. (2017), Validation of an MRI Rating Scale for Amyloid-Related Imaging Abnormalities. Journal of Neuroimaging. doi:10.1111/jon.12422, which has been published in final form at http://dx.doi.org/10.1111/jon.12422. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords: ARIA (amyloid-related imaging abnormalities), Alzheimer's disease (AD), MRI (magnetic resonance imaging), amyloid beta (Aβ), immunotherapy
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
URI: https://discovery.ucl.ac.uk/id/eprint/1542250
Downloads since deposit
138Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item