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Epigenome-wide association studies for cancer biomarker discovery in circulating cell-free DNA: technical advances and challenges

Tanic, M; Beck, S; (2017) Epigenome-wide association studies for cancer biomarker discovery in circulating cell-free DNA: technical advances and challenges. Current Opinion in Genetics and Development , 42 pp. 48-55. 10.1016/j.gde.2017.01.017. Green open access

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Abstract

Since introducing the concept of epigenome-wide association studies (EWAS) in 2011, there has been a vast increase in the number of published EWAS studies in common diseases, including in cancer. These studies have increased our understanding of epigenetic events underlying carcinogenesis and have enabled the discovery of cancer-specific methylation biomarkers. In this mini-review, we have focused on the state of the art in EWAS applied to cell-free circulating DNA for epigenetic biomarker discovery in cancer and discussed associated technical advances and challenges, and our expectations for the future of the field.

Type: Article
Title: Epigenome-wide association studies for cancer biomarker discovery in circulating cell-free DNA: technical advances and challenges
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.gde.2017.01.017
Publisher version: http://dx.doi.org/10.1016/j.gde.2017.01.017
Language: English
Additional information: © 2017 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio
URI: https://discovery.ucl.ac.uk/id/eprint/1541273
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