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Renin-Angiotensin System Blockade Improves Cardiac Indices in Acromegaly Patients

Thomas, JDJ; Dattani, A; Zemrak, F; Burchell, T; Akker, SA; Kaplan, FJL; Khoo, B; ... Korbonits, M; + view all (2017) Renin-Angiotensin System Blockade Improves Cardiac Indices in Acromegaly Patients. Experimental and Clinical Endocrinology & Diabetes , 125 (6) pp. 365-367. 10.1055/s-0042-123710. Green open access

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Abstract

PURPOSE: Blockade of the angiotensin-renin system, with angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs), has been shown to improve cardiac outcomes following myocardial infarction and delay progression of heart failure. Acromegaly is associated with a disease-specific cardiomyopathy, the pathogenesis of which is poorly understood. METHODS: The cardiac indices of patients with active acromegaly with no hypertension (Group A, n=4), established hypertension not taking ACEi/ARBs (Group B, n=4) and established hypertension taking ACEi/ARBs (Group C, n=4) were compared using cardiac magnetic imaging. RESULTS: Patients taking ACEi/ARBs had lower end diastolic volume index (EDVi) and end systolic volume index (ESVi) than the other 2 groups ([C] 73.24 vs. [A] 97.92 vs. [B] 101.03 ml/m2, ANOVA p=0.034, B vs. C p<0.01). Groups A and B had EDVi and ESVi values at the top of published reference range values; Group C had values in the middle of the range. CONCLUSIONS: Acromegaly patients on ACEi/ARBs for hypertension demonstrate improved cardiac indices compared to acromegaly patients with hypertension not taking these medications. Further studies are needed to determine if these drugs have a beneficial cardiac effect in acromegaly in the absence of demonstrable hypertension.

Type: Article
Title: Renin-Angiotensin System Blockade Improves Cardiac Indices in Acromegaly Patients
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1055/s-0042-123710
Publisher version: http://dx.doi.org/10.1055/s-0042-123710
Language: English
Additional information: Available under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) licence (https://creativecommons.org/licenses/by-nc-sa/4.0/).
Keywords: pituitary, acromegaly, cardiac magnetic resonance, renin-angiotensin
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1540763
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