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Established and new biologic therapies for psoriatic arthritis and psoriasis

Thomas, BJ; Elyoussfi, S; Ciurtin, C; (2016) Established and new biologic therapies for psoriatic arthritis and psoriasis. In: Biologics in Rheumatology: New Developments, Clinical Uses and Health Implication. (pp. 307-345). Nova Science Publishers: New York, NY, USA. Green open access

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Abstract

Psoriatic arthritis (PsA) is part of the group of seronegative spondyloarthropathies (SpA). These diseases share common clinical features such as sacroiliitis, spondylitis, enthesitis, psoriasis, uveitis, and genetic markers. The newly developed biologic treatments aim to target molecular and cellular abnormalities associated with autoimmunity in PsA and psoriasis. There are several biologic agents which are currently used, or are under investigation in both diseases, which creates an opportunity for rheumatologists and dermatologists to share their expertise for patients’ benefit. Apart from the large body of evidence for efficacy of the licensed biologic therapies in psoriasis and PsA, research efforts are currently put into discovering and testing new molecular targets with therapeutic potential. This chapter will review all the biologic agents ever tested in these two diseases, stratified based on the level of evidence regarding their efficacy. As PsA and psoriasis have a diverse clinical phenotype, it is useful to identify which treatments are effective for a particular clinical manifestation, such as axial and peripheral arthritis, dactylitis, enthesitis, skin and nail disease. Another aspect of biologic treatment effectiveness that will be explored in this chapter is the impact of these agents on patients’ quality of life and functional ability. We propose that by analysing the patient’s individual disease phenotype, based on clinical assessments and biomarkers, there is a huge opportunity to optimise the cost-effectiveness of biologic treatments, by facilitating tailored treatment options for patients with PsA and psoriasis.

Type: Book chapter
Title: Established and new biologic therapies for psoriatic arthritis and psoriasis
ISBN-13: 9781634852746
Open access status: An open access version is available from UCL Discovery
Publisher version: https://novapublishers.com/shop/biologics-in-rheum...
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/1538893
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