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Biologic treatments (other than anti-TNF therapy) licensed for use in rheumatoid arthritis

Attipoe, L; Bechman, K; Ciurtin, C; (2016) Biologic treatments (other than anti-TNF therapy) licensed for use in rheumatoid arthritis. In: Biologics in Rheumatology: New Developments, Clinical Uses and Health Implication. (pp. 229-258). Nova Science Publishers: New York, NY, USA. Green open access

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Abstract

Despite the huge progress made by the use of tumour necrosis factor (TNF) inhibitors in the treatment of rheumatoid arthritis (RA), there was still an unmet need for discovering and implementing new biologic therapies for RA patients who lost response or had side-effects to TNF inhibitors. The advances in molecular biology and understanding of the complex pathogenesis of RA enabled the identification of other pivotal molecules, whose blockage was associated with clinical benefits in RA. This chapter reviews the clinical efficacy, safety profile and cost-effectiveness of several biologic agents licensed for use in RA patients, which target different interleukins (IL), such as IL1 (anakinra) and IL6 (tocilizumab), or are associated with B cell depletion (rituximab), T cell co-stimulatory blockage (abatacept) and small molecule inhibition (tofacitinib). In addition, we discuss the national and international guidelines for use of these biologic agents in relation to the use of TNF inhibitors in patients with moderatesevere RA, providing examples of switching between various biologic therapies.

Type: Book chapter
Title: Biologic treatments (other than anti-TNF therapy) licensed for use in rheumatoid arthritis
ISBN-13: 9781634852746
Open access status: An open access version is available from UCL Discovery
Publisher version: https://novapublishers.com/shop/biologics-in-rheum...
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/1538873
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