Tiberi, S;
Scardigli, A;
Centis, R;
D'Ambrosio, L;
Muñoz-Torrico, M;
Salazar-Lezama, MÁ;
Spanevello, A;
... Caminero Luna, JA; + view all
(2016)
Classifying new anti-tuberculosis drugs: Rationale and future perspectives.
International Journal of Infectious Diseases
, 56
pp. 181-184.
10.1016/j.ijid.2016.10.026.
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Abstract
The classification of anti-tuberculosis (TB) drugs is important as it helps the clinician to build an appropriate anti-TB regimen for multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB cases that do not fulfil the criteria for the shorter MDR-TB regimen. The World Health Organization (WHO) has recently approved a revision of the classification of new anti-TB drugs based on current evidence on each drug. In the previous WHO guidelines, the choice of drugs was based on efficacy and toxicity in a step-down manner, from group 1 first-line drugs and groups 2-5 second-line drugs, to group 5 drugs with potentially limited efficacy or limited clinical evidence. In the revised WHO classification, exclusively aimed at managing drug-resistant cases, medicines are again listed in hierarchical order from group A to group D. In parallel, a possible future classification is independently proposed. The aim of this viewpoint article is to describe the evolution in WHO TB classification (taking into account an independently proposed new classification) and recent changes in WHO guidance, while commenting on the differences between them. The latest evidence on the ex-group 5 drugs is also discussed.
Type: | Article |
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Title: | Classifying new anti-tuberculosis drugs: Rationale and future perspectives |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1016/j.ijid.2016.10.026 |
Publisher version: | http://dx.doi.org/10.1016/j.ijid.2016.10.026 |
Language: | English |
Additional information: | © 2016 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by- nc-nd/4.0/). |
Keywords: | Anti-TB drugs; MDR/XDR-TB; Fluoroquinolones; Linezolid; Bedaquiline; Delamanid |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
URI: | https://discovery.ucl.ac.uk/id/eprint/1538731 |
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