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Dual-mode CMOS analog front-end (AFE) for electrical impedance spectroscopy (EIS) systems

Valente, V; Jiang, D; Demosthenous, A; (2016) Dual-mode CMOS analog front-end (AFE) for electrical impedance spectroscopy (EIS) systems. In: Wheeler, B and Wang, MD, (eds.) [Proceedings] 2016 IEEE 38th Annual International Conference of the Engineering in Medicine and Biology Society (EMBC). (pp. pp. 1914-1917). Institute of Electrical and Electronics Engineers (IEEE) Green open access

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Abstract

This paper presents the operation of a dualmode wideband CMOS analog front-end (AFE) for electrical impedance spectroscopy. The chip combines two current-readout (CR) channels and four voltage-readout (VR) channels suitable for both bipolar and tetrapolar EIS analysis. The chip addresses the need for flexible readout units for real-time simultaneous single-cell and large scale tissue/organ analysis. Postlayout simulations show that the VR channel is capable of wideband operation up to 12 MHz with noise floor as low as 16.4 nV/Hz1/2. A 2-bit control allows to select between a high-frequency low-gain channel and a bandwidth-limited high-gain channel. Each VR channel occupies an area of 0.48 mm2. The CR channel is capable of 80 dB of dynamic range, by converting currents between 1 nA to 10μA, while achieving a noise floor of 1.4 pA/Hz1/2. An automatic gain control (AGC) unit can be enabled in order maintain the sensor signal within the ADC dynamic range. Each CR channel occupies an area of 0.21 mm2. The chip consumes between 290 μA and 690 μA per channel and operates from a 1.8 V supply. The chip will be part of a fully flexible and configurable dual-mode EIS systems for impedance sensors and bioimpedance analysis.

Type: Proceedings paper
Title: Dual-mode CMOS analog front-end (AFE) for electrical impedance spectroscopy (EIS) systems
Event: EMBC 2016: 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 16-20 August 2016, Orlando, Florida, USA
ISBN-13: 9781457702204
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/EMBC.2016.7591096
Publisher version: https://doi.org/10.1109/EMBC.2016.7591096
Language: English
Additional information: Copyright © 2016 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Keywords: Gain, Electrodes, Impedance, Dynamic range, Gain control, Choppers (circuits), Voltage measurement
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Electronic and Electrical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1538385
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