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Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders

Andreasson, U; Blennow, K; Zetterberg, H; (2016) Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring , 3 pp. 98-102. 10.1016/j.dadm.2016.05.005. Green open access

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Abstract

Most research on fluid biomarkers for central nervous system (CNS) disorders has so far been performed using cerebrospinal fluid (CSF) as the biomarker source. CSF has the advantage of being closer to the brain than serum or plasma with a relative enrichment of CNS-specific proteins that are present at very low concentrations in the blood and thus difficult to reliably quantify using standard immunochemical technologies. Recent technical breakthroughs in the field of ultrasensitive assays have started to change this. Here, we review the most established ultrasensitive quantitative technologies that are currently available to general biomarker laboratories and discuss their use in research on biomarkers for CNS disorders.

Type: Article
Title: Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.dadm.2016.05.005
Publisher version: http://dx.doi.org/10.1016/j.dadm.2016.05.005
Language: English
Additional information: Copyright © 2016 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Alzheimer's disease, Biomarkers, Blood, Central nervous system, Plasma, Serum, Ultrasensitive
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1538246
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