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Glial and neuronal markers in cerebrospinal fluid in different types of multiple sclerosis

Alba Mane-Martinez, M; Olsson, B; Bau, L; Matas, E; Cobo-Calvo, A; Andreasson, U; Blennow, K; ... Zetterberg, H; + view all (2016) Glial and neuronal markers in cerebrospinal fluid in different types of multiple sclerosis. Journal of Neuroimmunology , 299 pp. 112-117. 10.1016/j.jneuroim.2016.08.004. Green open access

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Abstract

In the present study, CSF concentrations of NFL, t-tau, p-tau, GFAP, S-100B, YKL-40, MCP-1, α-sAPP, β-sAPP, and Aβ38, Aβ40, Aβ42 were measured in 324 MS patients to test whether a correlation among the biomarkers exists and whether the profile of CSF biomarkers varies among the different types of MS. The CSF concentrations of NFL were significantly higher in RRMS while CSF concentrations of GFAP were higher in PPMS. CSF concentrations of NFL correlated with YKL-40 in CIS patients while CSF concentrations of GFAP correlated with YKL-40 in RRMS patients.

Type: Article
Title: Glial and neuronal markers in cerebrospinal fluid in different types of multiple sclerosis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jneuroim.2016.08.004
Publisher version: http://dx.doi.org/10.1016/j.jneuroim.2016.08.004
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Diagnostic-criteria, lesions, expression, protein, neurodegeneration, guidelines, astrocytes, conversion, diseases
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1537951
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