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Cardiac defects, nuchal edema and abnormal lymphatic development are not associated with morphological changes in the ductus venosus

Burger, NB; Haak, MC; Kok, E; de Groot, CJM; Shou, W; Scambler, PJ; Lee, Y; ... Bekker, MN; + view all (2016) Cardiac defects, nuchal edema and abnormal lymphatic development are not associated with morphological changes in the ductus venosus. Early Human Development , 101 pp. 39-48. 10.1016/j.earlhumdev.2016.05.017. Green open access

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Abstract

BACKGROUND: In human fetuses with cardiac defects and increased nuchal translucency, abnormal ductus venosus flow velocity waveforms are observed. It is unknown whether abnormal ductus venosus flow velocity waveforms in fetuses with increased nuchal translucency are a reflection of altered cardiac function or are caused by local morphological alterations in the ductus venosus. AIM: The aim of this study was to investigate if the observed increased nuchal translucency, cardiac defects and abnormal lymphatic development in the examined mouse models are associated with local changes in ductus venosus morphology. STUDY DESIGN: Mouse embryos with anomalous lymphatic development and nuchal edema (Ccbe1−/− embryos), mouse embryos with cardiac defects and nuchal edema (Fkbp12−/−, Tbx1−/−, Chd7fl/fl;Mesp1Cre, Jarid2−/− NE+ embryos) and mouse embryos with cardiac defects without nuchal edema (Tbx2−/−, Fgf10−/−, Jarid2−/− NE − embryos) were examined. Embryos were analyzed from embryonic day (E) 11.5 to 15.5 using markers for endothelium, smooth muscle actin, nerve tissue and elastic fibers. RESULTS: All mutant and wild-type mouse embryos showed similar, positive endothelial and smooth muscle cell expression in the ductus venosus at E11.5–15.5. Nerve marker and elastic fiber expression were not identified in the ductus venosus in all investigated mutant and wild-type embryos. Local morphology and expression of the used markers were similar in the ductus venosus in all examined mutant and wild-type embryos. CONCLUSIONS: Cardiac defects, nuchal edema and abnormal lymphatic development are not associated with morphological changes in the ductus venosus. Ductus venosus flow velocity waveforms most probably reflect intracardiac pressure.

Type: Article
Title: Cardiac defects, nuchal edema and abnormal lymphatic development are not associated with morphological changes in the ductus venosus
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.earlhumdev.2016.05.017
Publisher version: http://dx.doi.org/10.1016/j.earlhumdev.2016.05.017
Language: English
Additional information: Copyright © 2016 Elsevier Ireland Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0)
Keywords: Cardiac defect; Ductus venosus; Endothelium; Increased nuchal translucency; Morphology; Nuchal edema
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1537640
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