Micali, N;
Crous-Bou, M;
Treasure, J;
Lawson, EA;
(2017)
Association Between Oxytocin Receptor Genotype, Maternal Care, and Eating Disorder Behaviours in a Community Sample of Women.
EUROPEAN EATING DISORDERS REVIEW
, 25
(1)
pp. 19-25.
10.1002/erv.2486.
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Abstract
This study aimed to investigate associations between oxytocin receptor gene (OXT-R) polymorphisms (rs53576 and rs2254298), their interaction with maternal care (GxE), and ED behaviours in a community sample. We studied 3698 women from the Avon Longitudinal Study of Parents and Children (ALSPAC) who participated in a two-phase prevalence study of lifetime ED and had genotype data. The GG rs53576 genotype was associated with binge eating and purging, and the rs2254298 AG/AA genotype with restrictive eating lifetime. In addition, the rs2254298 AG/AA genotype interacted with poor maternal care to increase the odds of binge eating and purging (odds ratio = 4.40 (95% confidence intervals: 1.11–17.4)). This study replicates previous findings of an association between OXT-R polymorphisms and ED, and it is the first to show an interaction between OXT-R genotype and poor maternal care. As such, these findings highlight the important role of oxytocin in understanding the pathophysiology of ED.
| Type: | Article |
|---|---|
| Title: | Association Between Oxytocin Receptor Genotype, Maternal Care, and Eating Disorder Behaviours in a Community Sample of Women |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/erv.2486 |
| Publisher version: | http://dx.doi.org/10.1002/erv.2486 |
| Language: | English |
| Additional information: | © 2016 The Authors European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Social Sciences, Psychology, Clinical, Psychology, ALSPAC, eating disorders, oxytocin, gene-environment interaction, PARENTAL BONDING INSTRUMENT, ANOREXIA-NERVOSA, GENE OXTR, BULIMIA-NERVOSA, FOOD-INTAKE, POLYMORPHISMS, PSYCHOPATHOLOGY, TEMPERAMENT, DEPRESSION, SECRETION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1537576 |
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