UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Hyponatremia and cyst growth in neonatal polycystic kidney disease: a case for aquaretics?

Bockenhauer, D; (2017) Hyponatremia and cyst growth in neonatal polycystic kidney disease: a case for aquaretics? Pediatric Nephrology , 32 (5) pp. 721-723. 10.1007/s00467-017-3578-7. Green open access

[thumbnail of Bockenhauer_aquaretics in neonatal polycystic kidney disease rev 1clean.pdf]
Preview
Text
Bockenhauer_aquaretics in neonatal polycystic kidney disease rev 1clean.pdf - Accepted Version

Download (116kB) | Preview

Abstract

Hyponatremia is a common complication in neonatal polycystic kidney disease and is thought to be due to water retention. Aquaretics are drugs that promote free water excretion by blocking the arginine vasopressine receptor type 2 (AVPR2) in the collecting duct and thus impair urinary concentration. AVPR2 is also a key stimulant for cyclic AMP production in the collecting duct and in this way promotes cyst proliferation and pathologic kidney growth in autosomal dominant polycystic kidney disease (ADPKD). Consequently, the aquaretic tolvaptan is now used to slow down progression of ADPKD in adult patients. Whether this beneficial effect on retarding cystic disease progression also extends to recessive forms of polycystic kidney disease (PKD) is currently not known. A case report in this edition of Pediatric Nephrology touches on the intersecting indications for tolvaptan for both hyponatremia and cyst retardation in neonatal PKD and suggests that use for one indication may have beneficial effects on the other.

Type: Article
Title: Hyponatremia and cyst growth in neonatal polycystic kidney disease: a case for aquaretics?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00467-017-3578-7
Publisher version: http://doi.org/10.1007/s00467-017-3578-7
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Aquaretic, tolvaptan, ADPKD, ARPKD, hyponatremia
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1537477
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item