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Association between Plasma Homocysteine Levels and Neuronal Injury in HIV Infection

Ahlgren, E; Hagberg, L; Fuchs, D; Andersson, L-M; Nilsson, S; Zetterberg, H; Gisslen, M; (2016) Association between Plasma Homocysteine Levels and Neuronal Injury in HIV Infection. PLOS ONE , 11 (7) , Article e0158973. 10.1371/journal.pone.0158973. Green open access

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Abstract

OBJECTIVE: To investigate the role of homocysteine in neuronal injury in HIV infection. METHODS: Using a cross-sectional design and archived samples, we compared concentrations of plasma homocysteine and cerebrospinal fluid (CSF) neurofilament light protein (NFL), a sensitive marker of neuronal injury, in 83 HIV-1-infected subjects without antiretroviral treatment. We also analyzed plasma vitamin B12, serum folate, CSF, and plasma HIV RNA, the immune activation marker neopterin in CSF and serum, and albumin ratio as a marker of blood-brain barrier integrity. Twenty-two subjects provided a second sample median of 12.5 months after antiretroviral treatment initiation. RESULTS: A significant correlation was found between plasma homocysteine and CSF NFL concentrations in untreated individuals (r = 0.52, p < 0.0001). As expected, there was a significant inverse correlation between homocysteine and B12 (r = –0.41, p < 0.001) and folate (r = –0.40, p = < 0.001) levels. In a multiple linear regression analysis homocysteine stood out as an independent predictor of CSF NFL in HIV-1-infected individuals. The correlation of plasma homocysteine and CSF NFL was also present in the group receiving antiretroviral therapy (r = 0.51, p = 0.016). CONCLUSION: A correlation between plasma homocysteine and axonal injury, as measured by CSF NFL, was found in both untreated and treated HIV. While this study is not able to prove a causal

Type: Article
Title: Association between Plasma Homocysteine Levels and Neuronal Injury in HIV Infection
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0158973
Publisher version: http://doi.org/10.1371/journal.pone.0158973
Language: English
Additional information: © 2016 Ahlgren et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, IMMUNODEFICIENCY-VIRUS INFECTION, AIDS DEMENTIA COMPLEX, ANTIRETROVIRAL THERAPY, IMMUNE ACTIVATION, HYPERHOMOCYSTEINEMIA, METAANALYSIS, DEFICIENCY, METABOLISM, NEOPTERIN
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1537442
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