UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Reconstructing contralateral fiber tracts: methodological aspects of cerebello-thalamocortical pathway reconstruction

Palesi, F; Tournier, JD; Calamante, F; Muhlert, N; Castellazzi, G; Chard, D; D'Angelo, E; (2016) Reconstructing contralateral fiber tracts: methodological aspects of cerebello-thalamocortical pathway reconstruction. Functional Neurology , 31 (4) pp. 229-238. 10.11138/FNeur/2016.31.4.229. Green open access

[img]
Preview
Text
Wheeler-Kingshott_article.pdf - Published version

Download (1MB) | Preview
[img] Archive
drive-download-20170223T144217Z-001.zip - Accepted version

Download (4MB)

Abstract

The identification of pathways connecting the cerebral cortex with subcortical structures is critical to understanding how large-scale brain networks operate. The cerebellum, for example, is known to project numerous axonal bundles to thecerebral cortex passing through the thalamus. This paper focuses on the technical details of cerebello-thalamo-cortical pathway reconstruction using advanced diffusion MRI techniques in humans in vivo. Pathways reconstructed using seed/target placement on super-resolution maps, created with track density imaging (TDI), were compared with those reconstructed by defining regions of interest (ROIs) on non-diffusion weighted images (b0). We observed that the reconstruction of the pathways was more anatomically accurate when using ROIs placed on TDI rather than on b0 maps, while inter-subject variability and reproducibility were similar between the two methods. Diffusion indices along pathways showed a position-dependent specificity that will need to be taken into consideration in future clinical investigations.

Type: Article
Title: Reconstructing contralateral fiber tracts: methodological aspects of cerebello-thalamocortical pathway reconstruction
Location: Italy
Open access status: An open access version is available from UCL Discovery
DOI: 10.11138/FNeur/2016.31.4.229
Publisher version: http://dx.doi.org/10.11138/FNeur/2016.31.4.229
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cerebello-thalamo-cortical pathway, constrained spherical deconvolution, diffusion MRI, super-resolution, trackdensity imaging
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/1536480
Downloads since deposit
10Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item