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Rituximab in the treatment of inflammatory myopathies: a review

Fasano, S; Gordon, P; Hajji, R; Loyo, E; Isenberg, DA; (2017) Rituximab in the treatment of inflammatory myopathies: a review. Rheumatology , 56 (1) pp. 26-36. 10.1093/rheumatology/kew146. Green open access

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Abstract

Several uncontrolled studies have encouraged the use of rituximab (RTX) in patients with myositis. Unfortunately, the first placebo-phase trial to assess the efficacy of RTX in refractory myositis did not show a significant difference between the two treatment groups, and doubts have been expressed about its study design. In this review we present an up-to-date overview of the reported experiences of RTX therapy in myositis. A PubMed search was performed to find all the available cases of refractory myositis patients treated with RTX up to July 2015. The following terms were assessed: inflammatory myopathies OR anti-synthetase syndrome OR polymyositis OR dermatomyositis AND RTX. A total of 48 studies were included. We identified 458 patients with myositis treated with RTX. We found a rate of response to RTX of 78.3%. RTX can play a role in the management of patients with myositis, at least in those with positive myositis-specific autoantibodies.

Type: Article
Title: Rituximab in the treatment of inflammatory myopathies: a review
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/rheumatology/kew146
Publisher version: http://dx.doi.org/10.1093/rheumatology/kew146
Language: English
Additional information: This is a pre-copyedited, author-produced version of an article accepted for publication in Rheumatology following peer review. The version of record, Fasano, S; Gordon, P; Hajji, R; Loyo, E; Isenberg, DA; (2017) Rituximab in the treatment of inflammatory myopathies: a review. Rheumatology, 56 (1) pp. 26-36, is available online at: http://dx.doi.org/10.1093/rheumatology/kew146.
Keywords: anti-synthetase syndrome, dermatomyositis, inflammatory myopathies, polymyositis, rituximab
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/1536421
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