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Kidney disease in primary anti-phospholipid antibody syndrome

Gracia-Tello, B; Isenberg, D; (2017) Kidney disease in primary anti-phospholipid antibody syndrome. Rheumatology , 56 (7) pp. 1069-1080. 10.1093/rheumatology/kew307. Green open access

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Abstract

APS is an autoimmune disease defined by the presence of arterial or venous thrombotic events and/or pregnancy morbidity in patients who test positive for aPL. APS can be isolated (primary APS) or associated with other autoimmune diseases. The kidney is a major target organ in APS, and renal thrombosis can occur at any level within the vasculature of the kidney (renal arteries, intrarenal vasculature and renal veins). Histological findings vary widely, including ischaemic glomeruli and thrombotic lesions without glomerular or arterial immune deposits on immunofluorescence. Renal involvement in patients with definite APS is treated with long-term anticoagulants as warfarin, but new treatments are being tried. The aim of this article is to review the links between primary APS and kidney disease.

Type: Article
Title: Kidney disease in primary anti-phospholipid antibody syndrome
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/rheumatology/kew307
Publisher version: https://doi.org/10.1093/rheumatology/kew307
Language: English
Additional information: Copyright © The Author 2016. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. This is a pre-copyedited, author-produced version of an article accepted for publication in Rheumatology following peer review. The version of record [insert complete citation information here] is available online at: https://doi.org/10.1093/rheumatology/kew307
Keywords: anti-phospholipid antibodies, anti-phospholipid–associated nephropathy, kidney disease, primary anti-phospholipid syndrome, thrombosis, treatment
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/1536417
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