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A Probabilistic Method for Estimation of Bowel Wall Thickness in MR Colonography

Hampshire, T; Menys, A; Jaffer, A; Bhatnagar, G; Punwani, S; Atkinson, D; Halligan, S; ... Taylor, SA; + view all (2017) A Probabilistic Method for Estimation of Bowel Wall Thickness in MR Colonography. PLOS ONE , 12 (1) 10.1371/journal.pone.0168317. Green open access

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Abstract

MRI has recently been applied as a tool to quantitatively evaluate the response to therapy in patients with Crohn’s disease, and is the preferred choice for repeated imaging. Bowel wall thickness on MRI is an important biomarker of underlying inflammatory activity, being abnormally increased in the acute phase and reducing in response to successful therapy; however, a poor level of interobserver agreement of measured thickness is reported and therefore a system for accurate, robust and reproducible measurements is desirable. We propose a novel method for estimating bowel wall-thickness to improve the poor interobserver agreement of the manual procedure. We show that the variability of wall thickness measurement between the algorithm and observer measurements (0.25mm ± 0.81mm) has differences which are similar to observer variability (0.16mm ± 0.64mm).

Type: Article
Title: A Probabilistic Method for Estimation of Bowel Wall Thickness in MR Colonography
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0168317
Publisher version: http://dx.doi.org/10.1371/journal.pone.0168317
Language: English
Additional information: © 2017 Hampshire et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, CROHNS-DISEASE, SEGMENTATION
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1536030
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