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Effect of low-dose aspirin use on survival of patients with gastrointestinal malignancies; an observational study

Frouws, MA; Bastiaannet, E; Langley, RE; Chia, WK; van Herk-Sukel, MPP; Lemmens, VEPP; Putter, H; ... Liefers, GJ; + view all (2017) Effect of low-dose aspirin use on survival of patients with gastrointestinal malignancies; an observational study. British Journal of Cancer , 116 (3) pp. 405-413. 10.1038/bjc.2016.425. Green open access

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Abstract

BACKGROUND: Previous studies suggested a relationship between aspirin use and mortality reduction. The mechanism for the effect of aspirin on cancer outcomes remains unclear. The aim of this study was to evaluate aspirin use and survival in patients with gastrointestinal tract cancer. METHODS: Patients with gastrointestinal tract cancer diagnosed between 1998 and 2011 were included. The population-based Eindhoven Cancer Registry was linked to drug-dispensing data from the PHARMO Database Network. The association between aspirin use after diagnosis and overall survival was analysed using Cox regression models. RESULTS: In total, 13 715 patients were diagnosed with gastrointestinal cancer. A total of 1008 patients were identified as aspirin users, and 8278 patients were identified as nonusers. The adjusted hazard ratio for aspirin users vs nonusers was 0.52 (95% CI 0.44–0.63). A significant association between aspirin use and survival was observed for patients with oesophageal, hepatobiliary and colorectal cancer. CONCLUSIONS: Post-diagnosis use of aspirin in patients with gastrointestinal tract malignancies is associated with increased survival in cancers with different sites of origin and biology. This adds weight to the hypothesis that the anti-cancer effects of aspirin are not tumour-site specific and may be modulated through the tumour micro-environment.

Type: Article
Title: Effect of low-dose aspirin use on survival of patients with gastrointestinal malignancies; an observational study
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/bjc.2016.425
Publisher version: http://dx.doi.org/10.1038/bjc.2016.425
Language: English
Additional information: & 2017 Cancer Research UK. All rights reserved 0007 – 0920/17
Keywords: Science & Technology, Life Sciences & Biomedicine, Oncology, Colorectal-Cancer, Randomized-Trials, Adjuvant Therapy, Diagnosis, Risk, Mortality, Cohort, Prevention
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1535920
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