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Impact and cost-effectiveness of selective human papillomavirus vaccination of men who have sex with men

Lin, A; Ong, KJ; Hobbelen, P; King, E; Mesher, D; Edmunds, WJ; Sonnenberg, P; ... Jit, M; + view all (2016) Impact and cost-effectiveness of selective human papillomavirus vaccination of men who have sex with men. Clinical Infectious Diseases 10.1093/cid/ciw845. (In press). Green open access

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Abstract

BACKGROUND: Men who have sex with men (MSM) have a high lifetime risk of anogenital warts and cancers related to infection with human papillomavirus (HPV). They also benefit less from herd protection than heterosexual males in settings with female-only HPV vaccination. METHODS: We evaluated the potential health impact and cost-effectiveness of offering vaccination to MSM who visit genito-urinary medicine clinics. We used a mathematical model of HPV 6/11/16/18 sexual transmission within an MSM population in England, parameterised with sexual behaviour, GUM attendance, HPV prevalence, HIV prevalence, warts and cancer incidence data. Interventions considered were offering HPV vaccination to either HIV-positive MSM or MSM regardless of HIV status, for age bands 16-25, 16-30, 16-35 and 16-40 years. RESULTS: Substantial declines in anogenital warts and male HPV-related cancer incidence are projected to occur following an offer of vaccination to MSM. MSM not attending GUM clinics will partially benefit from herd protection. Offering vaccination to HIV-positive MSM up to age 40 is likely to be cost-effective if vaccine procurement and administration costs are below £96.50 a dose. At £48 a dose, offering vaccination to all MSM up to age 40 is likely to be cost-effective. CONCLUSIONS: Quadrivalent HPV vaccination of MSM via GUM clinics is likely to be an effective and cost-effective way of reducing the burden of HPV-related disease in MSM.

Type: Article
Title: Impact and cost-effectiveness of selective human papillomavirus vaccination of men who have sex with men
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/cid/ciw845
Publisher version: http://dx.doi.org/10.1093/cid/ciw845
Language: English
Additional information: Copyright © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: human papillomavirus, men who have sex with men, vaccination
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/1535190
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