Matsuzaki, M;
Kulkarni, B;
Kuper, H;
Wells, JC;
Ploubidis, GB;
Prabhakaran, P;
Gupta, V;
... Kinra, S; + view all
(2017)
Association of Hip Bone Mineral Density and Body Composition in a Rural Indian Population: The Andhra Pradesh Children and Parents Study (APCAPS).
PLOS ONE
, 12
(1)
, Article e0167114. 10.1371/journal.pone.0167114.
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Abstract
Background Fat mass is variably associated with bone mass, possibly due to differential mechanical and biological effects of fat mass. We examined the association of fat mass with bone mass in a lean population. Objective To investigate association between hip bone mineral density and fat and lean mass in a cross-sectional study from southern India. Design The Andhra Pradesh Children and Parents Study is a prospective cohort study in Hyderabad, India. In 2009–2012, the study collected data on anthropometric measures, bone mineral density (BMD), fat mass, and lean mass measured by dual-energy x-ray absorptiometry, and socioeconomic data of the adult participants (n = 1760; mean age = 34.9 years old for women; 2130 and 32.3 for men). Results The median BMI (kg/m2) was 20.1 kg/m2. Women had relatively higher fat mass as compared to men. In models adjusted for lean mass, there was an association between hip bone mineral density and fat mass in women (β (95% confidence interval): premenopausal 0.025 (0.006 to 0.045); postmenopausal 0.045 (0.014 to 0.076)) but not in men (0.001 (-0.012 to 0.0014)). The association between hip BMD and fat mass was stronger in postmenopausal than premenopausal women. Hip BMD was consistently associated with lean mass, in both men and women. Conclusions In this relatively lean population, lean mass was more consistently associated with hip BMD than fat mass. Weight gain through lean mass improvement may be a more reliable public health strategy for strengthening bone health in transitional settings.
| Type: | Article |
|---|---|
| Title: | Association of Hip Bone Mineral Density and Body Composition in a Rural Indian Population: The Andhra Pradesh Children and Parents Study (APCAPS) |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0167114 |
| Publisher version: | http://doi.org/10.1371/journal.pone.0167114 |
| Language: | English |
| Additional information: | Copyright © 2017 Matsuzaki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See for further information: https://creativecommons.org/licenses/by-nc/4.0/deed.en |
| Keywords: | Fats, Hip, Bone density, India, Bone and joint mechanics, Osteoporosis, Physiological parameters, Tobacco |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Education UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education > IOE - Social Research Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1535178 |
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