Koppes, S;
Ljubojevic Hadzavdic, S;
Jakasa, I;
Franceschi, N;
Riethmuller, C;
Jurakic Toncic, R;
Marinovic, B;
... Kezic, S; + view all
(2017)
Effect of allergens and irritants on levels of natural moisturizing factor and corneocyte morphology.
Contact Dermatitis
, 76
(5)
pp. 287-295.
10.1111/cod.12770.
Preview |
Text
Koppes_Effect_allergens_irritants.pdf - Published Version Download (892kB) | Preview |
Abstract
BACKGROUND: The irritant sodium lauryl sulfate (SLS) is known to cause a decrease in the stratum corneum level of natural moisturizing factor (NMF), which in itself is associated with changes in corneocyte surface topography. OBJECTIVE: To explore this phenomenon in allergic contact dermatitis. METHODS: Patch testing was performed on patients with previously positive patch test reactions to potassium dichromate (Cr), nickel sulfate (Ni), methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI), or p-phenylenediamine. Moreover, a control (pet.) patch and an irritant (SLS) patch were applied. After 3 days, the stratum corneum from tested sites was collected, and NMF levels and corneocyte morphology, expressed as the amount of circular nanosize objects, quantified according to the Dermal Texture Index (DTI), were determined. RESULTS: Among allergens, only MCI/MI reduced NMF levels significantly, as did SLS. Furthermore, only MCI/MI caused remarkable changes at the microscopic level; the corneocytes were hexagonal-shaped with pronounced cell borders and a smoother surface. The DTI was increased after SLS exposure but not after allergen exposure. CONCLUSIONS: MCI/MI significantly decreased NMF levels, similarly to SLS. The altered corneocyte morphology suggests that skin barrier damage plays a role in the pathogenesis of MCI/MI contact allergy. The DTI seems to differentiate reactions to SLS from those to the allergens tested, as SLS was the only agent that caused a DTI increase.
| Type: | Article |
|---|---|
| Title: | Effect of allergens and irritants on levels of natural moisturizing factor and corneocyte morphology |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/cod.12770 |
| Publisher version: | http://doi.org/10.1111/cod.12770 |
| Language: | English |
| Additional information: | Copyright © 2017 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. - Please note: The copyright line for this article was changed on 8 February 2018 after original online publication. |
| Keywords: | allergic contact dermatitis; Dermal Texture Index; irritant contact dermatitis; natural moisturizing factor |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1534668 |
Archive Staff Only
 |
View Item |
