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Porous Polymeric Films from Microbubbles Generated Using a T-Junction Microfluidic Device

Elsayed, M; Kothandaraman, A; Edirisinghe, M; Huang, J; (2016) Porous Polymeric Films from Microbubbles Generated Using a T-Junction Microfluidic Device. Langmuir , 32 (50) pp. 13377-13385. 10.1021/acs.langmuir.6b02890. Green open access

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Abstract

In this work, a simple microfluidic junction with a T geometry and coarse (200 μm diameter) capillaries was used to generate monodisperse microbubbles with an alginate polymer shell. Subsequently, these bubbles were used to prepare porous alginate films with good control over the pore structure. The lack of pore size, shape, and surface control in scalable forming of polymeric films is a major application-limiting drawback at present. Controlling the thinning process of the shell of the bubbles to tune the surface of the resulting structures was also explored. Films were prepared with nanopatterned surfaces by controlling the thinning of the bubble shell, with the aid of surfactants, to induce efficient bursting (fragmentation) of bubbles to generate nanodroplets, which become embedded within the film surface. This novel feature greatly expands and enhances the use of hydrophilic polymers in a wide range of biomedical applications, particularly in drug delivery and tissue engineering, such as studying cellular responses to different morphological surfaces.

Type: Article
Title: Porous Polymeric Films from Microbubbles Generated Using a T-Junction Microfluidic Device
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acs.langmuir.6b02890
Publisher version: http://doi.org/10.1021/acs.langmuir.6b02890
Language: English
Additional information: © 2016 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/toc/langd5/32/50
Keywords: Science & Technology, Physical Sciences, Technology, Chemistry, Multidisciplinary, Chemistry, Physical, Materials Science, Multidisciplinary, Chemistry, Materials Science, DRUG-DELIVERY, BUBBLES, INTERFACE, SCAFFOLDS, NANOPARTICLES, TECHNOLOGY, MORPHOLOGY, STABILITY, DYNAMICS, SIZE
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1534351
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