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In Vitro Hydrodynamic Assessment of a New Transcatheter Heart Valve Concept (the TRISKELE)

Rahmani, B; Tzamtzis, S; Sheridan, R; Mullen, MJ; Yap, J; Seifalian, AM; Burriesci, G; (2017) In Vitro Hydrodynamic Assessment of a New Transcatheter Heart Valve Concept (the TRISKELE). Journal of Cardiovascular Translational Research , 10 (2) pp. 104-115. 10.1007/s12265-016-9722-0. Green open access

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Abstract

This study presents the in vitro hydrodynamic assessment of the TRISKELE, a new system suitable for transcatheter aortic valve implantation (TAVI), aiming to mitigate the procedural challenges experienced with current technologies. The TRISKELE valve comprises three polymeric leaflet and an adaptive sealing cuff, supported by a novel fully retrievable self-expanding nitinol wire frame. Valve prototypes were manufactured in three sizes of 23, 26, and 29 mm by automated dip-coating of a biostable polymer, and tested in a hydrodynamic bench setup in mock aortic roots of 21, 23, 25, and 27 mm annulus, and compared to two reference valves suitable for equivalent implantation ranges: Edwards SAPIEN XT and Medtronic CoreValve. The TRISKELE valves demonstrated a global hydrodynamic performance comparable or superior to the controls with significant reduction in paravalvular leakage. The TRISKELE valve exhibits enhanced anchoring and improved sealing. The valve is currently under preclinical investigation.

Type: Article
Title: In Vitro Hydrodynamic Assessment of a New Transcatheter Heart Valve Concept (the TRISKELE)
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s12265-016-9722-0
Publisher version: http://doi.org/10.1007/s12265-016-9722-0
Language: English
Additional information: Copyright © The Author(s) 2016. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Polymeric leaflets, Preclinical assessment, Self-expanding stent, TAVI
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1534171
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