Zabihian, B;
Chen, Z;
Rank, E;
Sinz, C;
Bonesi, M;
Sattmann, H;
Ensher, J;
... Liu, M; + view all
(2016)
Comprehensive vascular imaging using optical coherence tomography-based angiography and photoacoustic tomography.
Journal of Biomedical Optics
, 21
(9)
, Article 096011. 10.1117/1.JBO.21.9.096011.
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Abstract
Studies have proven the relationship between cutaneous vasculature abnormalities and dermatological disorders, but to image vasculature noninvasively in vivo, advanced optical imaging techniques are required. In this study, we imaged a palm of a healthy volunteer and three subjects with cutaneous abnormalities with photoacoustic tomography (PAT) and optical coherence tomography with angiography extension (OCTA). Capillaries in the papillary dermis that are too small to be discerned with PAT are visualized with OCTA. From our results, we speculate that the PA signal from the palm is mostly from hemoglobin in capillaries rather than melanin, knowing that melanin concentration in volar skin is significantly smaller than that in other areas of the skin. We present for the first time OCTA images of capillaries along with the PAT images of the deeper vessels, demonstrating the complementary effective imaging depth range and the visualization capabilities of PAT and OCTA for imaging human skin in vivo. The proposed imaging system in this study could significantly improve treatment monitoring of dermatological diseases associated with cutaneous vasculature abnormalities.
| Type: | Article |
|---|---|
| Title: | Comprehensive vascular imaging using optical coherence tomography-based angiography and photoacoustic tomography |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1117/1.JBO.21.9.096011 |
| Publisher version: | http://doi.org/10.1117/1.JBO.21.9.096011 |
| Language: | English |
| Additional information: | © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. [DOI: 10.1117/1.JBO.21.9.096011] |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Physical Sciences, Biochemical Research Methods, Optics, Radiology, Nuclear Medicine & Medical Imaging, Biochemistry & Molecular Biology, photoacoustic tomography, optical coherence tomography, angiography, human skin, capillary, papillary dermis, DIABETES-MELLITUS, OCT ANGIOGRAPHY, SWEPT SOURCE, SKIN, PSORIASIS, LESIONS, SYSTEM |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1534168 |
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