Weber, J;
Beard, PC;
Bohndiek, SE;
(2016)
Contrast agents for molecular photoacoustic imaging.
Nature Methods
, 13
(8)
pp. 639-650.
10.1038/NMETH.3929.
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Abstract
Photoacoustic imaging (PAI) is an emerging tool that bridges the traditional depth limits of ballistic optical imaging and the resolution limits of diffuse optical imaging. Using the acoustic waves generated in response to the absorption of pulsed laser light, it provides noninvasive images of absorbed optical energy density at depths of several centimeters with a resolution of ~100 μm. This versatile and scalable imaging modality has now shown potential for molecular imaging, which enables visualization of biological processes with systemically introduced contrast agents. Understanding the relative merits of the vast range of contrast agents available, from small-molecule dyes to gold and carbon nanostructures to liposome encapsulations, is a considerable challenge. Here we critically review the physical, chemical and biochemical characteristics of the existing photoacoustic contrast agents, highlighting key applications and present challenges for molecular PAI.
| Type: | Article |
|---|---|
| Title: | Contrast agents for molecular photoacoustic imaging |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/NMETH.3929 |
| Publisher version: | http://doi.org/10.1038/NMETH.3929 |
| Language: | English |
| Additional information: | © 2016 Nature America, Inc. All rights reserved. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Walled Carbon Nanotubes, Multispectral Optoacoustic Tomography, Conjugated Polymer Nanoparticles, In-vitro Characterization, Science-and-technology, Coated Gold Nanorods, Breast-cancer Cells, Indocyanine Green, Living Mice, Squaraine Dye |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1534167 |
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