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From PK/PD to QSP: Understanding the Dynamic Effect of Cholesterol-Lowering Drugs on Atherosclerosis Progression and Stratified Medicine

Pichardo-Almarza, C; Diaz-Zuccarini, V; (2016) From PK/PD to QSP: Understanding the Dynamic Effect of Cholesterol-Lowering Drugs on Atherosclerosis Progression and Stratified Medicine. Current Pharmaceutical Design , 22 (46) pp. 6903-6910. 10.2174/1381612822666160905095402. Green open access

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Abstract

Current computational and mathematical tools are demonstrating the high value of using systems modeling approaches (e.g. Quantitative Systems Pharmacology) to understand the effect of a given compound on the biological and physiological mechanisms related to a specific disease. This review provides a short survey of the evolution of the mathematical approaches used to understand the effect of particular cholesterol-lowering drugs, from pharmaco-kinetic (PK) / pharmaco-dynamic (PD) models, through physiologically base pharmacokinetic models (PBPK) to QSP. These mathematical models introduce more mechanistic information related to the effect of these drugs on atherosclerosis progression and demonstrate how QSP could open new ways for stratified medicine in this field.

Type: Article
Title: From PK/PD to QSP: Understanding the Dynamic Effect of Cholesterol-Lowering Drugs on Atherosclerosis Progression and Stratified Medicine
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.2174/1381612822666160905095402
Publisher version: http://www.eurekaselect.com/node/145337/article/fr...
Language: English
Additional information: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0 - https://creativecommons.org/licenses/by/4.0/legalcode).
Keywords: Quantitative Systems Pharmacology (QSP), cholesterol-lowering drugs, statins, atherosclerosis, mathematical modeling, simulation, personalized medicine
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1533312
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