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Post-translational modifications of lipid-activated nuclear receptors: Focus on metabolism

Becares Salles, N; Gage, MC; Pineda-Torra, I; (2017) Post-translational modifications of lipid-activated nuclear receptors: Focus on metabolism. Endocrinology , 158 (2) pp. 213-225. 10.1210/en.2016-1577. Green open access

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Abstract

Post-translational modifications (PTM) occur to nearly all proteins, are catalysed by specific enzymes and are subjected to tight regulation. They have been shown to be a powerful means by which the function of proteins can be modified resulting in diverse effects. Technological advances such as the increased sensitivity of mass spectrometry-based techniques and availability of mutant animal models have enhanced our understanding of the complexities of their regulation and the effect they have on protein function. However, the role that PTMs have in a pathological context still remains unknown for the most part. PTMs enable the modulation of nuclear receptor function in a rapid and reversible manner in response to varied stimuli, thereby dramatically altering their activity in some cases. This review will focus on acetylation, phosphorylation, sumoylation and O-GlcNAcylation, which are the four most studied PTMs affecting lipid-regulated nuclear receptor biology, and the implications of such modifications on metabolic pathways under homeostatic and pathological situations. Moreover, we review recent studies on the modulation of PTMs as therapeutic targets for metabolic diseases.

Type: Article
Title: Post-translational modifications of lipid-activated nuclear receptors: Focus on metabolism
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1210/en.2016-1577
Publisher version: http://doi.org/10.1210/en.2016-1577
Language: English
Additional information: This article has been published under the terms of the Creative Commons Attribution License (CC-BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s).
Keywords: Metabolism; acetylation; metabolic diseases; phosphorylation; protein processing, post-translational; enzymes; lipids; receptors; nuclear; protein sumoylation; liver x receptors
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1533307
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