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Protective effect of medicinal plants used in cancer prevention by traditional healers in Thailand

Lumlerdkij, N; Boonrak, R; Pongsitthichok, S; Wipanso, H; Akarasereenont, P; Heinrich, M; (2016) Protective effect of medicinal plants used in cancer prevention by traditional healers in Thailand. Planta Medica , 81 (S 01) S1-S381. 10.1055/s-0036-1596906. Green open access

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Abstract

Based on a field work focusing on cancer prevention by traditional healers in Thailand suggested that prevention of oxidative stress is one of the key aims. Oxidative stress is involved with degenerative diseases, as well as cancer initiation and progression [1]. Therefore, protective effect against oxidative stress-induced cell death was used to investigate cancer chemopreventive properties of plant extracts. HepG2 cells were incubated with plant extracts or (-)-Epigallocatechin gallate (EGCG) (positive control) at their non-toxic concentrations for 24 hours before an induction of the cell deaths using tert-butyl hydroperoxide (t-BHP). The Alamar Blue assay was used to determine the cell viability. After 0.5 mM t-BHP treatment for 3 hours, the viability of non-pre-treated cells was around 30%. EGCG at 50µM increased the viability to 48%. Nineteen extracts increased the viability while twelve extracts decreased the viability and six of them had no effect. Water extracts from Terminalia bellirica (Gaertn.) Roxb. and Aucklandia lappa DC. gave the highest protection by increasing the viability to 59% and 54%, respectively. In conclusion, half of the extracts from plants used traditionally in cancer prevention possess protective effect against oxidative stress-induced cell death. Further pharmacological investigation based on the key strategy will provide more detailed scientific evidence for assessing these traditional medical methods in cancer prevention.

Type: Article
Title: Protective effect of medicinal plants used in cancer prevention by traditional healers in Thailand
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1055/s-0036-1596906
Publisher version: http://dx.doi.org/10.1055/s-0036-1596906
Language: English
Additional information: © Georg Thieme Verlag KG Stuttgart · New York - https://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1596906
Keywords: Cancer prevention, chemoprevention, traditional medicine, oxidative stress.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > SoP Pharmaceutical and Bio Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1533159
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