Busuttil, F;
Rahim, AA;
Phillips, JB;
(2017)
Combining gene and stem cell therapy for peripheral nerve tissue engineering.
Stem Cells and Development
, 26
(4)
pp. 231-238.
10.1089/scd.2016.0188.
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Abstract
Despite a substantially increased understanding of neuropathophysiology, insufficient functional recovery after peripheral nerve injury (PNI) remains a significant clinical challenge. Nerve regeneration following injury is dependent on Schwann cells, the supporting cells in the peripheral nervous system. Following nerve injury, Schwann cells adopt a pro-regenerative phenotype which supports and guides regenerating nerves. However, this phenotype may not persist long enough to ensure functional recovery. Tissue engineered nerve repair devices containing therapeutic cells that maintain the appropriate phenotype may help enhance nerve regeneration. The combination of gene and cell therapy is an emerging experimental strategy which seeks to provide the optimal environment for axonal regeneration and re-establishment of functional circuits. This review aims to summarise current pre-clinical evidence with potential for future translation from bench to bedside.
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