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Multiple sclerosis, a treatable disease

Doshi, A; Chataway, J; (2016) Multiple sclerosis, a treatable disease. Clinical Medicine , 16 (Suppl 6) s53-s59. 10.7861/clinmedicine.16-6-s53. Green open access

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Abstract

This article reviews our current understanding and modern treatment of multiple sclerosis (MS). MS is a disabling condition resulting in devastating social and economic impacts. As MS can affect any part of the central nervous system, the presentation is often diverse; however, there are key features that can be useful in the clinic. We comment on the diagnostic criteria and review the main subtypes of MS, including clinically isolated syndrome, relapsing remitting MS, secondary progressive MS and primary progressive MS. Although the underlying aetiology of MS is still not known, we summarise those with most evidence of association. Finally, we aim to present treatment strategies for managing the acute relapse, disease-modifying therapies and MS symptoms. This review highlights that progressive MS is an area where there is currently a paucity of available disease-modifying treatments and this will be a major focus for future development.

Type: Article
Title: Multiple sclerosis, a treatable disease
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.7861/clinmedicine.16-6-s53
Publisher version: http://dx.doi.org/10.7861/clinmedicine.16-6-s53
Language: English
Additional information: Copyright © Royal College of Physicians 2016. All rights reserved.
Keywords: Diagnostic criteria, epidemiology, multiple sclerosis, progressive multiple sclerosis, treatments
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/1532669
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