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The use of Multiple Breath Washout for Assessing Cystic Fibrosis in Infants

Davies, G; Aurora, P; (2016) The use of Multiple Breath Washout for Assessing Cystic Fibrosis in Infants. Expert Review of Respiratory Medicine , 11 (1) pp. 21-28. 10.1080/17476348.2017.1269604. Green open access

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Abstract

INTRODUCTION: Lung Clearance Index, measured using the multiple breath washout (MBW) technique, may be a useful test in infants with Cystic Fibrosis (CF). However, the requirement for specialised equipment and a number of important technical and methodological considerations relevant to testing in infants have complicated matters, and to date prevented its widespread translatability in this age group. Areas covered: We review the current status of infant MBW testing in CF, focusing on Lung Clearance Index. This includes a review of recent developments in the field relevant to testing methodology in the infant population, use in evaluating lung disease in CF in infancy, and the associated challenges which remain. Expert commentary: The challenges of infant MBW are not limited to those associated with testing equipment, but also gaps in our understanding regarding the interpretation of MBW indices in infants. This includes their relationship to underlying physiology and pathology, and tracking over time. Recent advances in understanding and improving the infant MBW test set up (including both hardware and software) relevant to infants will greatly progress the field.

Type: Article
Title: The use of Multiple Breath Washout for Assessing Cystic Fibrosis in Infants
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/17476348.2017.1269604
Publisher version: http://dx.doi.org/10.1080/17476348.2017.1269604
Language: English
Additional information: This is an Accepted Manuscript of an article published by Taylor & Francis in the Expert Review of Respiratory Medicine on 7 December 2016, available online: http://www.tandfonline.com/10.1080/17476348.2017.1269604.
Keywords: Clinical trials, Cystic fibrosis, Infant lung function, Lung Clearance Index, Multiple Breath Washout
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1532187
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