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Hypomagnesemia and increased risk of new-onset diabetes mellitus after transplantation in pediatric renal transplant recipients

Bockenhauer, D; Hayes, W; Boyle, S; Carroll, A; Marks, S; (2017) Hypomagnesemia and increased risk of new-onset diabetes mellitus after transplantation in pediatric renal transplant recipients. Paediatric Nephrology , 32 (5) pp. 879-884. 10.1007/s00467-016-3571-6. Green open access

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Abstract

Background: New onset diabetes after transplantation (NODAT) is a significant co-morbidity following kidney transplantation. Lower post-transplant serum magnesium levels have been found to be an independent risk factor for NODAT in adult kidney transplant recipients. / Methods: We undertook a retrospective analysis of risk factors for NODAT in pediatric renal transplant recipients at our institution with the aim of determining if hypomagnesemia confers a significant risk of developing NODAT in children. / Results: One hundred and seventy three children with median age at transplantation 7.0 (range: 1.3 – 17.5) years were included. Hypomagnesemia was a significant independent risk factor for NODAT (p = 0.01). High trough tacrolimus levels were also independently associated with NODAT (p < 0.001). There was no significant association between NODAT and children’s BMI at the time of transplantation, monthly cumulative steroid dose or post transplant CMV viremia (p = 0.9, 0.6 and 0.7 respectively). / Conclusions: This study identifies hypomagnesemia as a significant independent risk factor for developing NODAT in pediatric renal transplant recipients. Given the clear association between hypomagnesemia and NODAT in both adults and children following renal transplantation, further studies are merited to clarify the etiology of this association, and to examine the effect of magnesium supplementation on NODAT.

Type: Article
Title: Hypomagnesemia and increased risk of new-onset diabetes mellitus after transplantation in pediatric renal transplant recipients
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00467-016-3571-6
Publisher version: http://dx.doi.org/10.1007/s00467-016-3571-6
Language: English
Additional information: © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
URI: https://discovery.ucl.ac.uk/id/eprint/1532184
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