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MarvelD3 regulates the c-Jun N-terminal kinase pathway during eye development in Xenopus.

Vacca, B; Sanchez-Heras, E; Steed, E; Balda, MS; Ohnuma, SI; Sasai, N; Mayor, R; (2016) MarvelD3 regulates the c-Jun N-terminal kinase pathway during eye development in Xenopus. Biol Open , 5 (11) pp. 1631-1641. 10.1242/bio.018945. Green open access

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Abstract

Ocular morphogenesis requires several signalling pathways controlling the expression of transcription factors and cell-cycle regulators. However, despite a well-known mechanism, the dialogue between those signals and factors remains to be unveiled. Here, we identify a requirement for MarvelD3, a tight junction transmembrane protein, in eye morphogenesis in Xenopus MarvelD3 depletion led to an abnormally pigmented eye or even an eye-less phenotype, which was rescued by ectopic MarvelD3 expression. Altering MarvelD3 expression led to deregulated expression of cell-cycle regulators and transcription factors required for eye development. The eye phenotype was rescued by increased c-Jun terminal Kinase activation. Thus, MarvelD3 links tight junctions and modulation of the JNK pathway to eye morphogenesis.

Type: Article
Title: MarvelD3 regulates the c-Jun N-terminal kinase pathway during eye development in Xenopus.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1242/bio.018945
Publisher version: http://dx.doi.org/10.1242/bio.018945
Language: English
Additional information: © 2016. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/3.0This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
Keywords: C-Jun N-terminal Kinase, MarvelD3, Tight junction, Xenopus eye
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1531027
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