UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

White matter tract abnormalities are associated with cognitive dysfunction and secondary progressive multiple sclerosis

Thompson, AJ; Meijer, KA; Muhlert, N; Sethi, V; Ron, MA; Miller, DH; Chard, D; ... Cercignani, M; + view all (2016) White matter tract abnormalities are associated with cognitive dysfunction and secondary progressive multiple sclerosis. Multiple Sclerosis Journal , 22 (11) pp. 1429-1437. 10.1177/1352458515622694. Green open access

[thumbnail of Thompson_Accepted_main_document_07112015.pdf]
Preview
Text
Thompson_Accepted_main_document_07112015.pdf - Accepted Version

Download (448kB) | Preview

Abstract

BACKGROUND: While our knowledge of white matter (WM) pathology underlying cognitive impairment in relapsing remitting multiple sclerosis (MS) is increasing, equivalent understanding in those with secondary progressive (SP) MS lags behind. OBJECTIVE: The aim of this study is to examine whether the extent and severity of WM tract damage differ between cognitively impaired (CI) and cognitively preserved (CP) secondary progressive multiple sclerosis (SPMS) patients. METHODS: Conventional magnetic resonance imaging (MRI) and diffusion MRI were acquired from 30 SPMS patients and 32 healthy controls (HC). Cognitive domains commonly affected in MS patients were assessed. Linear regression was used to predict cognition. Diffusion measures were compared between groups using tract-based spatial statistics (TBSS). RESULTS: A total of 12 patients were classified as CI, and processing speed was the most commonly affected domain. The final regression model including demographic variables and radial diffusivity explained the greatest variance of cognitive performance (R2 = 0.48, p = 0.002). SPMS patients showed widespread loss of WM integrity throughout the WM skeleton when compared with HC. When compared with CP patients, CI patients showed more extensive and severe damage of several WM tracts, including the fornix, superior longitudinal fasciculus and forceps major. CONCLUSION: Loss of WM integrity assessed using TBSS helps to explain cognitive decline in SPMS patients

Type: Article
Title: White matter tract abnormalities are associated with cognitive dysfunction and secondary progressive multiple sclerosis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/1352458515622694
Publisher version: http://dx.doi.org/10.1177/1352458515622694
Language: English
Additional information: Copyright © The Author(s), 2016.
Keywords: Multiple sclerosis, secondary progressive, MRI, cognition, myelination, DTI
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/1530982
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item