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Low-grade epilepsy-associated neuroepithelial tumours - the 2016 WHO classification

Bluemcke, I; Aronica, E; Becker, A; Capper, D; Coras, R; Honavar, M; Jacques, TS; ... Thom, M; + view all (2016) Low-grade epilepsy-associated neuroepithelial tumours - the 2016 WHO classification. Nature Reviews Neurology , 12 pp. 732-740. 10.1038/nrneurol.2016.173. Green open access

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Abstract

Rapid developments in molecular genetic technology and research have swiftly advanced our understanding of neuro-oncology. As a consequence, the WHO invited their expert panels to revise the current classification system of brain tumours and to introduce, for the first time, a molecular genetic approach for selected tumour entities, thus setting a new gold standard in histopathology. The revised 5th edition of the 'blue book' was released in May 2016 and will have a major impact in stratifying diagnosis and treatment. However, low-grade neuroepithelial tumours that present with early-onset focal epilepsy and are mostly seen in children and young adults (previously designated as long-term epilepsy-associated neuroepithelial tumours, LEAT) lack such innovative clinicopathological and molecular genetic tools. The Neuropathology Task Force of the International League against Epilepsy will critically discuss this issue, and will offer perspectives on how to decipher and validate clinically meaningful LEAT entities using the current WHO approach that integrates clinicopathological and genetic classification systems.

Type: Article
Title: Low-grade epilepsy-associated neuroepithelial tumours - the 2016 WHO classification
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nrneurol.2016.173
Publisher version: http://doi.org/10.1038/nrneurol.2016.173
Language: English
Additional information: © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Keywords: CNS cancer, Diagnosis, Epilepsy, Paediatric cancer
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1530524
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