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Attachment, Neurobiology, and Mentalizing along the Psychosis Continuum

Debbane, M; Salaminios, G; Luyten, P; Badoud, D; Armando, M; Tozzi, AS; Fonagy, P; (2016) Attachment, Neurobiology, and Mentalizing along the Psychosis Continuum. Frontiers in Human Neuroscience , 10 , Article 406. 10.3389/finhum.2016.00406. Green open access

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Abstract

In this review article, we outline the evidence linking attachment adversity to psychosis, from the premorbid stages of the disorder to its clinical forms. To better understand the neurobiological mechanisms through which insecure attachment may contribute to psychosis, we identify at least five neurobiological pathways linking attachment to risk for developing psychosis. Besides its well documented influence on the hypothalamic-pituary-adrenal (HPA) axis, insecure attachment may also contribute to neurodevelopmental risk through the dopaminergic and oxytonergic systems, as well as bear influence on neuroinflammation and oxidative stress responses. We further consider the neuroscientific and behavioral studies that underpin mentalization as a suite of processes potentially moderating the risk to transition to psychotic disorders. In particular, mentalization may help the individual compensate for endophenotypical impairments in the integration of sensory and metacognitive information. We propose a model where embodied mentalization would lie at the core of a protective, resilience response mitigating the adverse and potentially pathological influence of the neurodevelopmental cascade of risk for psychosis.

Type: Article
Title: Attachment, Neurobiology, and Mentalizing along the Psychosis Continuum
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/finhum.2016.00406
Publisher version: https://doi.org/10.3389/fnhum.2016.00406
Language: English
Additional information: Copyright © 2016 Debbané, Salaminios, Luyten, Badoud, Armando, Solida Tozzi, Fonagy and Brent. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: schizophrenia, mentalizing, HPA, schizotypy, UHR, theory of mind, self
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/1529468
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